National award to Anthony Melvin Crasto for contribution to Pharma society from Times Network for Excellence in HEALTHCARE) | 5th July, 2018 | Taj Lands End, Mumbai, India

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DR ANTHONY MEVIN CRASTO Conferred prestigious individual national award at function for contribution to Pharma society from Times Network, National Awards for Marketing Excellence ( For Excellence in HEALTHCARE) | 5th July, 2018 | Taj Lands End, Mumbai India

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////////////National award,  contribution to Pharma society, Times Network, Excellence in HEALTHCARE,  5th July, 2018, Taj Lands End, Mumbai,  India, ANTHONY CRASTO




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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, NO ADVERTISEMENTS , ACADEMIC , NON COMMERCIAL SITE, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution, …………….+91 9323115463

2014 in review

The stats helper monkeys prepared a 2014 annual report for this blog.

Here’s an excerpt:

The concert hall at the Sydney Opera House holds 2,700 people. This blog was viewed about 9,700 times in 2014. If it were a concert at Sydney Opera House, it would take about 4 sold-out performances for that many people to see it.

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Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations

Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations
Huan Zhang, Hiroki Tanimoto, Tsumoru Morimoto, Yasuhiro Nishiyama, Kiyomi Kakiuchi
Org. Lett. 2013, 15, 5222-5225.

Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also −90 °C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.






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Dr Paul Murray is a world leading consultant scientist, providing expertise and training in the fields of Catalysis, Design of Experiments and Principal Component Analysis. Paul is an experienced scientist with an additional expertise in automation, multivariate data analysis, process development and problem solving. Paul has a proven track record of the timely delivery of innovative solutions to client projects resulting in significant reductions in costs and resources to customers.

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Azaheterocycles Made Easy

thumbnail image: Azaheterocycles Made Easy

Azaheterocycles Made Easy
Flexible route makes azaheterocycles easier to access


Azaheterocycles are a highly important class of compounds due to their biological activities and pharmaceutical applications. In particular, dihydroazepines, dihydropyrroles, and pyrroles are constituents of a valuable privileged structure in organic chemistry.

Read more

Fermentation of hydrolysate detoxified by pervaporation through block copolymer membranes

Graphical abstract: Fermentation of hydrolysate detoxified by pervaporation through block copolymer membranes

Fermentation of hydrolysate detoxified by pervaporation through block copolymer membranes


The large-scale use of lignocellulosic hydrolysate as a fermentation broth has been impeded due to its high concentration of organic inhibitors to fermentation. In this study, pervaporation with polystyrene-block-polydimethylsiloxane-block-polystyrene (SDS) block copolymer membranes was shown to be an effective method for separating volatile inhibitors from dilute acid pretreated hydrolysate, thus detoxifying hydrolysate for subsequent fermentation. We report the separation of inhibitors from hydrolysate thermodynamically and quantitatively by detailing their concentrations in the hydrolysate before and after detoxification by pervaporation. Specifically, we report >99% removal of furfural and 27% removal of acetic acid with this method. Additionally, we quantitatively report that the membrane is selective for organic inhibitor compounds over water, despite water’s smaller molecular size. Because its inhibitors were removed but its sugars left intact, pervaporation-detoxified hydrolysate was suitable for fermentation. In our fermentation experiments, Saccharomyces cerevisiae strain SA-1 consumed the glucose in pervaporation-detoxified hydrolysate, producing ethanol. In contrast, under the same conditions, a control hydrolysate was unsuitable for fermentation; no ethanol was produced and no glucose was consumed. This work demonstrates progress toward economical lignocellulosic hydrolysate fermentation.



Corresponding authors
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, USA 
E-mail: ;
Tel: +1 (510) 642-8937
Department of Bioengineering, University of California, Berkeley, USA 
E-mail: ;
Tel: +1 (510) 643-5678
Energy Biosciences Institute, University of California, Berkeley, USA
Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA
Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, USA
Green Chem., 2014, Advance Article

DOI: 10.1039/C4GC00756E











Received 28 Apr 2014, Accepted 24 Jun 2014
First published online 11 Jul 2014

Hydrolysate was pervaporated with a block copolymer membrane, removing inhibitors but leaving sugars, creating a viable fermentation broth.