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National award to Anthony Melvin Crasto for contribution to Pharma society from Times Network for Excellence in HEALTHCARE) | 5th July, 2018 | Taj Lands End, Mumbai, India

DR ANTHONY MELVIN CRASTO Ph.D ANTHONY MELVIN CRASTO, Conference, Synthesis , , , , , , , , ,

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DR ANTHONY MEVIN CRASTO Conferred prestigious individual national award at function for contribution to Pharma society from Times Network, National Awards for Marketing Excellence ( For Excellence in HEALTHCARE) | 5th July, 2018 | Taj Lands End, Mumbai India

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////////////National award,  contribution to Pharma society, Times Network, Excellence in HEALTHCARE,  5th July, 2018, Taj Lands End, Mumbai,  India, ANTHONY CRASTO

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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, NO ADVERTISEMENTS , ACADEMIC , NON COMMERCIAL SITE, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution, ……..amcrasto@gmail.com……….+91 9323115463
 
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2014 in review

DR ANTHONY MELVIN CRASTO Ph.D ANTHONY MELVIN CRASTO, Synthesis

The WordPress.com stats helper monkeys prepared a 2014 annual report for this blog.

Here’s an excerpt:

The concert hall at the Sydney Opera House holds 2,700 people. This blog was viewed about 9,700 times in 2014. If it were a concert at Sydney Opera House, it would take about 4 sold-out performances for that many people to see it.

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Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations

DR ANTHONY MELVIN CRASTO Ph.D ANTHONY MELVIN CRASTO, CATALYSIS, ORGANIC CHEMISTRY ,

Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations”
Huan Zhang, Hiroki Tanimoto, Tsumoru Morimoto, Yasuhiro Nishiyama, Kiyomi Kakiuchi
Org. Lett. 2013, 15, 5222-5225.

http://pubs.acs.org/doi/abs/10.1021/ol402387w

Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also −90 °C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.

CATALYSIS CONSULTING ………..DR PAUL MURRAY ON A ROLL IN CATALYSIS ARENA

DR ANTHONY MELVIN CRASTO Ph.D CATALYSIS , ,

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DR PAUL MURRAY  LEFTSIDE IN BLACK SUIT

NICE TO MEET HIM AT SCIENTIFIC UPDATE OPRD CONFERENCE IN PUNE INDIA DEC 5 2014.

WEBSITE

http://www.catalysisconsulting.co.uk/

Paul Murray Catalysis Consulting helps companies to save money and resources through more efficient chemical processes.

About

Dr Paul Murray is a world leading consultant scientist, providing expertise and training in the fields of Catalysis, Design of Experiments and Principal Component Analysis. Paul is an experienced scientist with an additional expertise in automation, multivariate data analysis, process development and problem solving. Paul has a proven track record of the timely delivery of innovative solutions to client projects resulting in significant reductions in costs and resources to customers.

Dr Paul Murray

Paul Murray Catalysis Consulting provides expertise in:

  • The development and optimisation of challenging catalytic reactions.
  • The use of Principal Component Analysis (PCA) to optimise ligand and solvent selection.
  • The use of advanced experimental design linking DoE with PCA for efficient reaction development.
  • The development and use of automation for reaction screening including catalyst screening.
  • The development of chemical reactions across all stages from identification and exploitation of new chemical reaction selectivity’s through to commercial manufacture.
  • Homogeneous, heterogeneous and bio catalysis.

Consultancy

Paul Murray Catalysis Consulting offers consultancy in all aspects of Catalysis, Design of Experiments, Principal Component Analysis, solvent selection and process development.

  1. Design of Experiments to efficiently identify important reaction parameters and optimise processes:
    • Selection of the appropriate designs, factors and ranges for an experimental investigation.
    • The analysis and interpretation of the experimental data.
    • The prediction of reaction outcomes from the Design of Experiments model.
  2. Principal Component Analysis to rationalise diverse sets of materials such as solvents:
    • Selection of suitable properties for chemical datasets to generate appropriate PCA maps.
    • Selection of materials from PCA maps to enable the efficient understanding of the chemical space and requirements of the chemical reaction.
    • Selection of the appropriate designs and analysis of experimental data.
    • Partial Least Squares (PLS) modelling to understand the properties of materials that play a significant role in optimum reaction development and prediction of suitability of additional materials for the chosen reaction.
  3. Catalysis:
    • Homogeneous, heterogeneous and bio catalysis
    • Recommendation of reaction conditions for an array of transformations.
    • Guide experimental programs to optimise processes including the selection of the optimum catalyst and ligand.
    • Detailed analysis of reaction outcomes to diagnose the source of the trouble.
    • Optimisation of a commercial manufacturing process to make a sustainable and economically viable long term process.
    • Design of new shorter synthetic routes that fully exploit the opportunities presented by catalysis.

Azaheterocycles Made Easy

DR ANTHONY MELVIN CRASTO Ph.D ANTHONY MELVIN CRASTO, medicinal chemistry, ORGANIC CHEMISTRY, Synthesis ,

thumbnail image: Azaheterocycles Made Easy

Azaheterocycles Made Easy
Flexible route makes azaheterocycles easier to access

 

Azaheterocycles are a highly important class of compounds due to their biological activities and pharmaceutical applications. In particular, dihydroazepines, dihydropyrroles, and pyrroles are constituents of a valuable privileged structure in organic chemistry.

Read more

 

http://www.chemistryviews.org/details/ezine/6508611/Azaheterocycles_Made_Easy.html

Fermentation of hydrolysate detoxified by pervaporation through block copolymer membranes

DR ANTHONY MELVIN CRASTO Ph.D ORGANIC CHEMISTRY , , , , , ,

Graphical abstract: Fermentation of hydrolysate detoxified by pervaporation through block copolymer membranes

Fermentation of hydrolysate detoxified by pervaporation through block copolymer membranes

 

The large-scale use of lignocellulosic hydrolysate as a fermentation broth has been impeded due to its high concentration of organic inhibitors to fermentation. In this study, pervaporation with polystyrene-block-polydimethylsiloxane-block-polystyrene (SDS) block copolymer membranes was shown to be an effective method for separating volatile inhibitors from dilute acid pretreated hydrolysate, thus detoxifying hydrolysate for subsequent fermentation. We report the separation of inhibitors from hydrolysate thermodynamically and quantitatively by detailing their concentrations in the hydrolysate before and after detoxification by pervaporation. Specifically, we report >99% removal of furfural and 27% removal of acetic acid with this method. Additionally, we quantitatively report that the membrane is selective for organic inhibitor compounds over water, despite water’s smaller molecular size. Because its inhibitors were removed but its sugars left intact, pervaporation-detoxified hydrolysate was suitable for fermentation. In our fermentation experiments, Saccharomyces cerevisiae strain SA-1 consumed the glucose in pervaporation-detoxified hydrolysate, producing ethanol. In contrast, under the same conditions, a control hydrolysate was unsuitable for fermentation; no ethanol was produced and no glucose was consumed. This work demonstrates progress toward economical lignocellulosic hydrolysate fermentation.

 

 

 
*
Corresponding authors
a
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, USA 
E-mail: nbalsara@berkeley.edu ;
Tel: +1 (510) 642-8937
b
Department of Bioengineering, University of California, Berkeley, USA 
E-mail: aparkin@lbl.gov ;
Tel: +1 (510) 643-5678
c
Energy Biosciences Institute, University of California, Berkeley, USA
d
Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA
e
Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, USA
Green Chem., 2014, Advance Article


DOI: 10.1039/C4GC00756E

 

 

 

 

 

 

 

 

 

 

Received 28 Apr 2014, Accepted 24 Jun 2014
First published online 11 Jul 2014

Hydrolysate was pervaporated with a block copolymer membrane, removing inhibitors but leaving sugars, creating a viable fermentation broth.

Anthony crasto’s blog New drug approvals touches 3 lakh views…….Helping millions

DR ANTHONY MELVIN CRASTO Ph.D Synthesis ,

link is http://newdrugapprovals.org/

 

All about Drugs, live, by DR ANTHONY MELVIN CRASTO, Worlddrugtracker, Helping millions, 7 million hits on google, pushing boundaries, one lakh plus connections worldwide, 3 lakh plus VIEWS on this blog in 193 countries

 

 

 

 

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Chiral Tin Participates in Radical Cyclizations

DR ANTHONY MELVIN CRASTO Ph.D Synthesis , , , ,

 

Chiral tin hydrides generate radicals and transfer chirality in the cyclization of aldehydes
This offers an insight for the future design of catalytic asymmetric radical reactions.

Read more

http://www.chemistryviews.org/details/ezine/5446641/Chiral_Tin_Participates_in_Radical_Cyclizations.html

Rapid Wolff-Kishner reductions in a silicon carbide microreactor

DR ANTHONY MELVIN CRASTO Ph.D Synthesis , , , , ,

Green Chem., 2013, Advance Article
DOI: 10.1039/C3GC41942H, Paper
Stephen G. Newman, Lei Gu, Christoph Lesniak, Georg Victor, Frank Meschke, Lahbib Abahmane, Klavs F. Jensen
Wolff-Kishner reductions are performed continuously in a silicon carbide microreactor. Short reactions times and safe operation are achieved, giving high yields without reactor corrosion issues using just 1.5 equivalents of hydrazine.

Rapid Wolff-Kishner reductions in a silicon carbide microreactor

http://pubs.rsc.org/en/Content/ArticleLanding/2013/GC/C3GC41942H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams