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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, NO ADVERTISEMENTS , ACADEMIC , NON COMMERCIAL SITE, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution, ……..amcrasto@gmail.com……….+91 9323115463
 

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

Green Chem., 2015, 17,852-855
DOI: 10.1039/C4GC02325K, Communication
*Corresponding authors
aDepartment of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London, UK
bDepartment of Chemistry, University College London, Christopher-Ingold Building, 20 Gordon Street, London, UK
Green Chem., 2015,17, 852-855

DOI: 10.1039/C4GC02325K

Royal Society of Chemistry
image file: c4gc02325k-s1.tif
Scheme 1 Overview of the biocatalytic and non-enzymatic cascades presented in this work, including the ‘triangular’ cascade.
image file: c4gc02325k-u1.tif
image file: c4gc02325k-u2.tif
image file: c4gc02325k-s2.tif
Scheme 2 One-pot chemoenzymatic synthesis of (S)-4 and (S)-5. Reaction conditions: (a) 20 mM 2, 10 mM sodium pyruvate, 500 μg mL−1 NCS and 20% v.v−1 CV2025 lysate, 50 mM HEPES pH 7.5, 37 °C, 3 h. (b) 40 mM formaldehyde, 1 M sodium phosphate, pH 6, 30 min, 37 °C.
Prof Helen Hailes
Appointment
  • Professor of Chemical Biology
  • Dept of Chemistry
  • Faculty of Maths & Physical Sciences
Research Summary
Research activity in our group is focused on the use of synthetic organic chemistry to probe and solve biological problems. Current projects include the use of water as a reaction solvent and the use of catalytic and biocatalytic synthetic strategies. Also novel kinase inhibitors, cytosine-based hydrogen-bonding polymers and new lipid design for use in a ternary gene delivery vector.
Academic Background
1991 PhD Doctor of Philosophy – Organic Chemistry University of Cambridge
1987 BA Bachelor of Arts – Chemistry and Metallurgy University of Cambridge

publications..total 146

https://iris.ucl.ac.uk/iris/browse/profile?upi=HCHAI24

9 Research Activities
Status

Dr. Swamy Sreenivasa……..Department of Chemistry, Tumkur University

Dr. Swamy Sreenivasa……..Department of Chemistry, Tumkur University

Dr. Swamy Sreenivasa……..Department of Chemistry, Tumkur University, India

abstract graphic

N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Character­ization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.

Molbank 20132013(3), M803; doi:10.3390/M803
Short Note

N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide

Dr. S. Sreenivasa 
Associate Professor,                        Tumkur University
email………..drsreenivasa@yahoo.co.in. 
1 Center for Advanced Materials, Department of Chemistry, Tumkur University, Tumkur-572103, India2 Tadimety Aromatics Pvt. Ltd, Hirehalli Industrial Area, Tumkur-572168, India
* Author to whom correspondence should be addressed.
Synthesis of N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3)
compound (3) as a colorless solid with Rf = 0.79.
Yield: 1.63 g (90%).
Melting point: 151–153 °C.
MS: m/z = 277.64 (M++1).
IR: νmax/cm−1: 3340 (N-H), 2228 (CN), 1698 (CO), 1342–1140 (CF3 streching).
1H-NMR (DMSO-d6) δ: 10.47 (s, 1H, NH), 7.88 (d, J = 8.7 Hz, 1H, Ar-H), 7.80 (d, J = 1.9 Hz, 1H,
Ar-H), 7.45 (dd, J = 8.3 Hz and J = 1.5 Hz, 1H, Ar-H), 2.74 (t, J = 7.5 Hz, 2H, COCH2),
2.67–2.55 (m, 2H, CF3CH2).
13C-NMR (DMSO-d6) δ: 169.3, 141.2, 138.3, 134.8, 128.7 CF3, 125.9, 124.6, 115.9, 104.9, 28.7, 27.8.
Elemental analysis: Calculated for C11H8ClF3N2O: C, 47.76%; H, 2.91%; N, 10.13%. Found: C,
47.79%; H, 2.96%; N, 10.19%.

Center for Advanced Materials, Department of Chemistry, Tumkur University, Tumkur-572103, India
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Aralaguppe, Tumkur
The elevated highway between Nelamangala and Yeshwanthpur junction on Tumkur Road, National
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Benne Idli Sagu at Pavithra Idli Hotel, Kyathasandra Tumkur

http://blog.kudugal.org/2011/09/second-storm-aka-whirlwind-2-day-1.html

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Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations

Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations
Huan Zhang, Hiroki Tanimoto, Tsumoru Morimoto, Yasuhiro Nishiyama, Kiyomi Kakiuchi
Org. Lett. 2013, 15, 5222-5225.

http://pubs.acs.org/doi/abs/10.1021/ol402387w

Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also −90 °C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.

FACILE MULTI-DECAGRAM SYNTHESIS OF METHYL BUT-2-YNOATE

“Facile multi-decagram synthesis of methyl but-2-ynoate” B. Darses, I. N. Michaelides, D. J. Dixon, Org. Chem. Front. 2014, 1, 117-119

Facile multi-decagram synthesis of methyl but-2-ynoate

 *Corresponding authors
aDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK
Org. Chem. Front., 2014,1, 117-119

DOI: 10.1039/C3QO00072A

http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/c3qo00072a#!

A high yielding and operationally simple protocol affords multi-decagram quantities of the synthetically useful methyl but-2-ynoate from commercially available starting materials and reagents.

Graphical abstract: Facile multi-decagram synthesis of methyl but-2-ynoate

MOLINSTINCTS ID:0001-5u7q

Formula:C5H6O2

IUPAC Name:methyl but-2-ynoate

Cite this record :MIID:0001-5u7q

methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate C-NMR spectrum
methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate H-NMR spectrum

Synthesis Route for 23326-27-4

67-56-1
Methanol
590-93-2
but-2-ynoic acid
~67%
23326-27-4
methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

Synthesis Route for 23326-27-4

4344-87-0
3-Methyl-3-pyraz…
67-56-1
Methanol
~61%
23326-27-4
methyl but-2-yno…

Reference:

Moriarty, Robert M.; Vaid, Radhe K.; Farid, Payman Journal of the Chemical Society, Chemical Communications, 1987 , # 10 p. 711 – 712

Synthesis Route for 23326-27-4

67-56-1
Methanol
108-26-9
3-methyl-1,4-dih…
~34%
23326-27-4
methyl but-2-yno…

Reference:

Myrboh, B.; Ila, H.; Junjappa, H. Synthesis, 1982 , # 12 p. 1100 – 1102

Synthesis Route for 23326-27-4

186581-53-3
diazomethane
590-93-2
but-2-ynoic acid
23326-27-4
methyl but-2-yno…

Reference:

Aberhart, D. John Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5218 – 5220

Synthesis Route for 23326-27-4

1743-62-0
~73%
23326-27-4
methyl but-2-yno…

Reference:

Boers, Rutger B.; Randulfe, Yolanda Pazos; Van Der Haas, Hendrikus N. S.; Van Rossum-Baan, Marleen; Lugtenburg, Johan European Journal of Organic Chemistry, 2002 , # 13 p. 2094 – 2108

Synthesis Route for 23326-27-4

67-56-1
Methanol
590-93-2
but-2-ynoic acid
~67%
23326-27-4
methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

 

 

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 


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Piecing together the puzzle: understanding a mild, metal free reduction method for large scale synthesis of hydrazines

 

 

Piecing together the puzzle: understanding a mild, metal free reduction method for large scale synthesis of hydrazines

D.L. Browne,* I.R. Baxendale, S.V. Ley, Tetrahedron 2011, 67, 10296-10303.

http://www.sciencedirect.com/science/article/pii/S0040402011015304

 

Full-size image (13 K)

 

A key intermediate for the synthesis of hydrazines via a mild, metal free reduction of diazonium salts has been isolated and characterized by X-ray analysis. The presence of this intermediate is general, as demonstrated by the preparation of a number of analogues. A discussion of the mechanism and potential benefits of such a process are also described.