////////////National award, contribution to Pharma society, Times Network, Excellence in HEALTHCARE, 5th July, 2018, Taj Lands End, Mumbai, India, ANTHONY CRASTO
#hotpersoninawheelchair
#worlddrugtracker
DOI: 10.1039/C4GC02325K
 |
||
| Scheme 1 Overview of the biocatalytic and non-enzymatic cascades presented in this work, including the ‘triangular’ cascade. | ||
 |
||
| Scheme 2 One-pot chemoenzymatic synthesis of (S)-4 and (S)-5. Reaction conditions: (a) 20 mM 2, 10 mM sodium pyruvate, 500 μg mL−1 NCS and 20% v.v−1 CV2025 lysate, 50 mM HEPES pH 7.5, 37 °C, 3 h. (b) 40 mM formaldehyde, 1 M sodium phosphate, pH 6, 30 min, 37 °C. | ||
| 1991 | PhD | Doctor of Philosophy – Organic Chemistry | University of Cambridge |
| 1987 | BA | Bachelor of Arts – Chemistry and Metallurgy | University of Cambridge |
publications..total 146
https://iris.ucl.ac.uk/iris/browse/profile?upi=HCHAI24
Dr. Swamy Sreenivasa……..Department of Chemistry, Tumkur University, India
N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.
|
Dr. S. Sreenivasa , Associate Professor, Tumkur University |
ತುಮಕೂರು ವಿಶ್ವವಿದ್ಯಾನಿಲಯTUMKUR UNIVERSITY |
http://www.tumakuruonline.in/city-guide/cuisine-of-tumkur
http://flickrhivemind.net/Tags/ddhills/Interesting
Benne Idli Sagu at Pavithra Idli Hotel, Kyathasandra Tumkur
http://blog.kudugal.org/2011/09/second-storm-aka-whirlwind-2-day-1.html
The WordPress.com stats helper monkeys prepared a 2014 annual report for this blog.
Here’s an excerpt:
The concert hall at the Sydney Opera House holds 2,700 people. This blog was viewed about 9,700 times in 2014. If it were a concert at Sydney Opera House, it would take about 4 sold-out performances for that many people to see it.
Click here to see the complete report.
Regioselective Rapid Synthesis of Fully-substituted 1,2,3-Triazoles Mediated by Propargyl Cations”
Huan Zhang, Hiroki Tanimoto, Tsumoru Morimoto, Yasuhiro Nishiyama, Kiyomi Kakiuchi
Org. Lett. 2013, 15, 5222-5225.
http://pubs.acs.org/doi/abs/10.1021/ol402387w
Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also −90 °C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.
“Facile multi-decagram synthesis of methyl but-2-ynoate” B. Darses, I. N. Michaelides, D. J. Dixon, Org. Chem. Front. 2014, 1, 117-119
DOI: 10.1039/C3QO00072A
http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/c3qo00072a#!
A high yielding and operationally simple protocol affords multi-decagram quantities of the synthetically useful methyl but-2-ynoate from commercially available starting materials and reagents.
CAS 23326-27-4MOLINSTINCTS ID:0001-5u7q
Formula:C5H6O2
IUPAC Name:methyl but-2-ynoate
Cite this record :MIID:0001-5u7q
|
|
|
Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351
|
|
|
Moriarty, Robert M.; Vaid, Radhe K.; Farid, Payman Journal of the Chemical Society, Chemical Communications, 1987 , # 10 p. 711 – 712
|
|
|
Myrboh, B.; Ila, H.; Junjappa, H. Synthesis, 1982 , # 12 p. 1100 – 1102
|
|
|
Aberhart, D. John Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5218 – 5220
|
|
|
Boers, Rutger B.; Randulfe, Yolanda Pazos; Van Der Haas, Hendrikus N. S.; Van Rossum-Baan, Marleen; Lugtenburg, Johan European Journal of Organic Chemistry, 2002 , # 13 p. 2094 – 2108
|
|
|
Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351
Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO …..FOR BLOG HOME CLICK HERE
Join me on twitter
Join me on google plus 
amcrasto@gmail.com
D.L. Browne,* I.R. Baxendale, S.V. Ley, Tetrahedron 2011, 67, 10296-10303.
http://www.sciencedirect.com/science/article/pii/S0040402011015304
A key intermediate for the synthesis of hydrazines via a mild, metal free reduction of diazonium salts has been isolated and characterized by X-ray analysis. The presence of this intermediate is general, as demonstrated by the preparation of a number of analogues. A discussion of the mechanism and potential benefits of such a process are also described.
Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.
Efficient synthesis of supported proline catalysts for asymmetric aldol reactions
A. A. Elmekawy,a J. B. Sweeneya and D. R. Brown*a
*Corresponding authors
aDepartment of Chemical Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK
E-mail: d.r.brown@hud.ac.uk;
Fax: +44 (0)1484 472182 ;
Tel: +44 (0)1484 47339
Catal. Sci. Technol., 2014, Advance Article
DOI: 10.1039/C4CY00970C
http://cen.acs.org/articles/92/i37/Copying-Natures-Assembly-Line.html
Reaction repeatedly inserts organolithium compound into carbon-boron bond, creating chains up to 10 carbons long
Copying Nature’s Assembly Line
Organic Synthesis: Successive homologation reactions let chemists tailor carbon chain’s conformation
Organic chemists have long admired nature for its ability to perform chemistry in an assembly-line style, wherein the same reaction or sets of reactions are carried out repeatedly to create a target molecule. Polyketide natural products, for example, are biosynthesized via such an assembly-line process.
Now, chemists at England’s University of Bristol report an assembly-line reaction that can be done in a flask (Nature 2014, DOI: 10.1038/nature13711).
