DOI: 10.1039/C3GC41942H, Paper
Wolff-Kishner reductions are performed continuously in a silicon carbide microreactor. Short reactions times and safe operation are achieved, giving high yields without reactor corrosion issues using just 1.5 equivalents of hydrazine.
Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams