Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CY/C4CY00970C?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fcy+%28RSC+-+Catalysis+Science+%26+Technology+latest+articles%29#!divAbstract

Efficient synthesis of supported proline catalysts for asymmetric aldol reactions
A. A. Elmekawy,a J. B. Sweeneya and D. R. Brown*a

*Corresponding authors
aDepartment of Chemical Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK
E-mail: d.r.brown@hud.ac.uk;
Fax: +44 (0)1484 472182 ;
Tel: +44 (0)1484 47339
Catal. Sci. Technol., 2014, Advance Article
DOI: 10.1039/C4CY00970C

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