Copying Nature’s Assembly Line Organic Synthesis: Successive homologation reactions let chemists tailor carbon chain’s conformation

09237-notw3-boronic_18037306-657

Reaction repeatedly inserts organolithium compound into carbon-boron bond, creating chains up to 10 carbons long.

http://cen.acs.org/articles/92/i37/Copying-Natures-Assembly-Line.html
Reaction repeatedly inserts organolithium compound into carbon-boron bond, creating chains up to 10 carbons long

Copying Nature’s Assembly Line

Organic Synthesis: Successive homologation reactions let chemists tailor carbon chain’s conformation
Organic chemists have long admired nature for its ability to perform chemistry in an assembly-line style, wherein the same reaction or sets of reactions are carried out repeatedly to create a target molecule. Polyketide natural products, for example, are biosynthesized via such an assembly-line process.
Now, chemists at England’s University of Bristol report an assembly-line reaction that can be done in a flask (Nature 2014, DOI: 10.1038/nature13711).

 

Advertisement

One thought on “Copying Nature’s Assembly Line Organic Synthesis: Successive homologation reactions let chemists tailor carbon chain’s conformation

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s