Going for Gold in Chiral Amine Synthesis
A diphosphine binuclear gold(I) chloride complex catalyzes the asymmetric hydroamination of alkenes
Amines are synthesized most effectively by hydroamination of unactivated alkenes, the enantioselective version of which is best achieved by metal catalysis. Binuclear gold(I) complexes can catalyze the hydroamination of alkenes, however, the harsh and stringent reactions conditions required have prevented full development of this metal for synthesis of chiral amines. In addition, the exact catalytic species involved and whether the activating silver salt participates haChiral Amine Synthesis remained a mystery.