Bronsted acid ionic liquid-catalyzed reductive Friedel-Crafts alkylation of indoles and cyclic ketones without using an external reductant

Green Chem., 2015, Advance Article
DOI: 10.1039/C4GC01299B, Communication
Amir Taheri, Bingbing Lai, Cheng Cheng, Yanlong Gu
C3-cycloalkylated indole was synthesized from indole and cyclic ketone in the absence of a reductant with the aid of an acid catalyst.
Bronsted acid ionic liquid-catalyzed reductive Friedel-Crafts alkylation of indoles and cyclic ketones without using an external reductant
In the absence of an external reductant, C3-cycloalkylated indole could be synthesized through reductive alkylation of indole with cyclic ketone using a sulfonyl-functionalized Brønsted acid ionic liquid as a catalyst. Water generated in the initial stage of the reaction played a key role in rendering the reductive coupling possible. The reaction proceeds most likely in a radical way.
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Microwave-Assisted Three-Component “Catalyst and Solvent-Free” Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans,

Green Chemistry International

851924.sch.001
Scheme 1: Synthesis of 4H-benzo[b]pyran derivatives under MW irradiation.

Microwave-Assisted Three-Component “Catalyst and Solvent-Free” Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans,

Organic Chemistry International
Volume 2014 (2014), Article ID 851924, 8 pages
http://dx.doi.org/10.1155/2014/851924

Sougata Santra, Matiur Rahman, Anupam Roy, Adinath Majee, and Alakananda Hajra
Volume 2014 (2014), Article ID 851924, 8 pages

http://www.hindawi.com/journals/oci/2014/851924/

A green and highly efficient method has been developed for the one-pot synthesis of tetrahydrobenzo[b]pyrans via a three-component condensation of aldehydes, 1,3-cyclic diketones, and malononitrile under MW irradiation without using any catalyst and solvent. This transformation presumably occurs by a sequential Knoevenagel condensation, Michael addition, and intramolecular cyclization. Operational simplicity, solvent and catalyst-free conditions, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure.

851924.sch.002
Scheme 2: Plausible reaction mechanism.
851924.sch.003

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Synthesis of Ibuprofen Using Silica-Supported Preyssler Nanoparticles as an Eco-Friendly, Inexpensive, and Efficient Catalyst,

New Drug Approvals

906801.sch.001
Scheme 1: Synthesis of ibuprofen using Silica-Supported Preyssler Nanoparticles (H14[NaP5W30O110]/SiO2) (SPNPs) using ethanol and pyridine in their reactions.

Synthesis of Ibuprofen Using Silica-Supported Preyssler Nanoparticles as an Eco-Friendly, Inexpensive, and Efficient Catalyst,

Organic Chemistry International
Volume 2014 (2014), Article ID 906801, 6 pages
http://dx.doi.org/10.1155/2014/906801

http://www.hindawi.com/journals/oci/2014/906801/

Ali Gharib,1,2 Nader Noroozi Pesyan,3 Leila Vojdani Fard,4 and Mina Roshani1

1Department of Chemistry, Islamic Azad University, Mashhad, Iran
2Agricultural Researches and Services Center, Mashhad, Iran
3Department of Chemistry, Faculty of Science, Urmia University, Urmia 57159, Iran
4Education Organization of Razavi Khorasan, Education Ministry, Mashhad, Iran
Received 5 January 2014; Revised 15 February 2014; Accepted 31 March 2014; Published 6 May 2014
Academic Editor: Jonathan White

Copyright © 2014 Ali Gharib et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any…

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I did not run away from a NaCN Exotherm

New Drug Approvals

Deltamethrin

DELTAMETHRIN

DID NOT RUN AWAY FROM NACN ie sodium cyanide EXOTHERM

ALMOST VIRTUAL ACCIDENT AT RPG LIFESCIENCES (SEARLE) PANOLI GUJARAT INDIA 1999-2000

DELTAMETHRIN PROJECT, 1999-2000 Panoli Gujarat India

ww were trying to add acid chloride into an aldehyde at zero degrees cent using PTC conditions and one of ingredient was sodium cyanide, cooling was done by brine

We  Did not run away when instead of adding acid chloride in 2 hrs the operator added it on 10 min…………..I waited at the reactor and controlled an exotherm in plant by switching off brine supply to other reactors,

The reaction got controlled at 59 deg cent and luckily was ok…………the exotherm was fearful.

Despite all odds God saves us

http://makeinindia.com/ MAKE IN INDIA
http://makeinindia.com/
http://makeinindia.com/sector/pharmaceuticals/

ANTHONY MELVIN CRASTO

THANKS AND REGARD’S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
web link

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A truly green synthesis of α-aminonitriles via Strecker reaction

Green Chemistry International

A truly green synthesis of α-aminonitriles via Strecker reaction

Debasish Bandyopadhyay, Juliana M Velazquez, Bimal K BanikOrganic and Medicinal Chemistry Letters 2011, 1:11 (4 October 2011)

Background
The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds.

Results
Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of α-aminonitriles from diverse amines, aldehydes and TMSCN. This general rapid method is applicable to a wide range of amines and aldehydes and produces products in excellent yield.

Conclusions
The present one-pot, three-component environmentally benign procedure for the synthesis of α-aminonitriles will find application in the synthesis of complex biologically active molecules.

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A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry

Green Chemistry International

A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry
Lakhinath Saikia, Jejiron Baruah, Ashim Thakur
Organic and Medicinal Chemistry Letters 2011, 1:12 (4 October 2011)

http://www.orgmedchemlett.com/content/1/1/12

Background
Synthesis of oximes is an important reaction in organic chemistry, because these versatile oximes are used for protection, purification, and characterization of carbonyl compounds. Nitriles, amides via Beckmann rearrangement, nitro compounds, nitrones, amines, and azaheterocycles can be synthesised from oximes. They also find applications for selective α-activation. In inorganic chemistry, oximes act as a versatile ligand.

Several procedures for the preparation of oximes exist, but, most of them have not addressed the green chemistry issue. They are associated with generation of pollutants, requirement of high reaction temperature, low yields, lack of a generalized procedure, etc. Hence, there is a demand for developing an efficient, convenient, and non-polluting or less polluting alternative method for the preparation of oximes. In…

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