A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry

Green Chemistry International

A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry
Lakhinath Saikia, Jejiron Baruah, Ashim Thakur
Organic and Medicinal Chemistry Letters 2011, 1:12 (4 October 2011)

http://www.orgmedchemlett.com/content/1/1/12

Background
Synthesis of oximes is an important reaction in organic chemistry, because these versatile oximes are used for protection, purification, and characterization of carbonyl compounds. Nitriles, amides via Beckmann rearrangement, nitro compounds, nitrones, amines, and azaheterocycles can be synthesised from oximes. They also find applications for selective α-activation. In inorganic chemistry, oximes act as a versatile ligand.

Several procedures for the preparation of oximes exist, but, most of them have not addressed the green chemistry issue. They are associated with generation of pollutants, requirement of high reaction temperature, low yields, lack of a generalized procedure, etc. Hence, there is a demand for developing an efficient, convenient, and non-polluting or less polluting alternative method for the preparation of oximes. In…

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