Thiotepa, チオテパ
- Use:antineoplastic, alkylating agent
- Chemical name:1,1′,1”-phosphinothioylidynetrisaziridine
- Formula:C6H12N3PS
- MW:189.22 g/mol
- CAS:52-24-4
- EINECS:200-135-7
- LD50:14500 μg/kg (M, i.v.); 38 mg/kg (M, p.o.);
9400 μg/kg (R, i.v.) - Aziridine, 1,1′,1”-phosphinothioylidynetris-Aziridine, 1-[bis(1-aziridinyl)phosphinothioyl]-N,N’,N”-TriethylenethiophosphoramidePhosphorothioic tri(ethyleneamide)SZ2975000T3NTJ APS&- AT3NTJ&- AT3NTJ [WLN]ThiofozilThiotef1,1′,1”-Phosphorothioyltriaziridine
JAPAN APPROVED, Rethio, PMDA, 2019/3/26
тиотепа [Russian] [INN]
ثيوتيبا [Arabic] [INN]
塞替派 [Chinese] [INN]
Thiotepa (INN,[1] chemical name: N,N′,N′′-triethylenethiophosphoramide) is an alkylating agent used to treat cancer.
Thiotepa is an organophosphorus compound with the formula SP(NC2H4)3.[2] It is an analog of N,N′,N′′-triethylenephosphoramide (TEPA), which contains tetrahedral phosphorus and is structurally akin to phosphate. It is manufactured by heating aziridine with thiophosphoryl chloride.
History
Thiotepa was developed…
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