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GLENMARK-A new way for a new world

New Drug Approvals

GlenmarkLogo.jpg

http://www.glenmarkpharma.com/GLN_NWS/homepage.aspx?res=P_GLN

http://www.glenmark-generics.com/

TypePublic
Traded asBSE532296NSEGLENMARK)
IndustryPharmaceuticalsDrugs &Healthcare
Founded1977
Founder(s)Gracias Saldanha
HeadquartersMumbaiMaharashtra[1]India
Key peopleGlenn Saldanha, MD & CEO [2]
ProductsMedicines and Vaccines
RevenueINR1031.10 crore(US$160 million) (2009–2010)[3]
Employees7,000 [4]
SubsidiariesGlenmark Generics Ltd[5]
Websitewww.glenmarkpharma.com

Glenmark Pharmaceuticals is a pharmaceutical company headquartered in MumbaiIndia[6] It manufactures and markets generic formulation products and active pharmaceutical ingredients (API), both in the domestic and international markets. In the formulation business, its business spans segments such as DermatologyInternal MedicinePaediatricsGynaecologyENT andDiabetes.

It has four manufacturing facilities for formulations and additional three facilities for APIs. These manufacturing facilities are located in the states of MaharashtraGoaHimachal Pradesh and Gujarat in India.

It…

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A communication pathway between two brain structures appears to control anxiety levels

TGI: Thrive Health

Our continued interest in understanding Mind-Brain-Body-Science, motivating us to follow the developments in this regard, more specifically communication channels in neural system.

To that end, this morning we came across the following article that explored the communication pathways that control anxiety levels. Tye* and her colleagues, in a step toward uncovering better targets,  have discovered a communication pathway between two brain structures that appears to control anxiety levels. By turning the volume of this communication up and down in mice, the researchers were able to boost and reduce anxiety levels.

The two brain structures that appear to involved in this process are: the amygdala and the ventral hippocampus

 How these two brain structures interact:

To study those interactions, the researchers turned to optogenetics, which allows them to engineer neurons to turn their electrical activity on or off in response to light. For this study, the researchers modified…

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ATORVASTATIN SYNTHESIS

New Drug Approvals

File:Atorvastatin2D.svg

atorvastatin

File:Atorvastatin3Dan.gif

Atorvastatin (INN/əˌtɔrvəˈstætən/, marketed by Pfizer as a calcium salt under the trade name Lipitor,[1] is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Like all statins, atorvastatin works by inhibitingHMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.

Atorvastatin was first synthesized in 1985 by Bruce Roth of Parke-Davis Warner-Lambert Company (since acquired by Pfizer). The best selling drug in pharmaceutical history, sales of Lipitor since it was approved in 1996 exceed US$125 billion, and the drug has topped the list of best-selling branded pharmaceuticals in the world for nearly a decade.[2] When Pfizer’s patent on…

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Iodine-mediated arylation of benzoxazoles with aldehydes

A simple and efficient methodology for the arylation of benzoxazoles with aldehydes using iodine as the mediator has been developed. The reaction proceeded smoothly with a range of substrates to give the corresponding arylated products in moderate to good yields

 

Green Chem., 2013, 15,2365-2368
DOI: 10.1039/C3GC41027G, Communication
*
Corresponding authors
a
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
E-mail: ygzhang@ibn.a-star.edu.sg ;
Fax: (+65) 6478-9020

A simple and efficient methodology for the arylation of benzoxazoles with aldehydes using iodine as the mediator has been developed

Direct synthesis of hydrogen peroxide in water in a continuous trickle bed reactor optimized to maximize productivity

 

Hydrogen peroxide direct synthesis was studied in continuous mode over a 5% wt Pd/C commercial catalyst in a Trickle Bed Reactor. The target of the study was to maximize the hydrogen peroxide production. The catalyst was uniformly diluted in quartz sand at different concentrations to investigate their effects on the direct synthesis.

The amount of catalyst and the distribution of the catalyst along the bed were optimized to obtain the highest possible yield. The distribution of the catalyst along the bed gave the possibility to significantly improve the selectivity and production of hydrogen peroxide (up to 0.5% under selected conditions). Higher production rate and selectivity were found when the catalyst concentration was decreased along the bed from the top to the bottom as compared to the uniformly dispersed catalyst.

The H2/Pd ratio was found to be an important parameter that has to be investigated in the hydrogen peroxide direct synthesis. The effect of a pretreatment of the catalyst with a solution of sodium bromide and phosphoric acid was studied; the results showed how a catalyst pretreatment can lead to a real green hydrogen peroxide synthesis in water. Some optimization guidelines are also provided.

 

 

Green Chem., 2013, 15,2502-2513
DOI: 10.1039/C3GC40811F, Paper
*
Corresponding authors
a
Department of Chemical Engineering, Åbo Akademi University, Turku/Åbo, Finland
E-mail: bpierdom@abo.fi ;
Fax: +358 2 215 4479 ;
Tel: +358 2 215 4555
b
Department of Chemical Engineering and Environmental Technology, University of Valladolid, Valladolid, Spain
E-mail: jgserna@iq.uva.es

Hydrogen peroxide direct synthesis was studied in continuous mode over a 5% wt Pd/C commercial catalyst in a Trickle Bed Reactor.