Microbial cyclosophoraose as a catalyst for the synthesis of diversified indolyl 4H-chromenes via one-pot three component reactions in water

Green Chemistry International

Green Chem., 2016, 18,3620-3627
DOI: 10.1039/C6GC00137H, Paper
Someshwar D. Dindulkar, Daham Jeong, Eunae Cho, Dongjin Kim, Seunho Jung
A novel biosourced saccharide catalyst, microbial cyclosophoraose, a cyclic [small beta]-(1,2) glucan, was used for the synthesis of indolyl 4H-chromenes via a one pot three-component Knoevenagel-Michael addition-cyclization reaction in water under neutral conditions.

Microbial cyclosophoraose as a catalyst for the synthesis of diversified indolyl 4H-chromenes via one-pot three component reactions in water

 *corresponding authors
a
Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 143-701, South Korea
E-mail: shjung@konkuk.ac.kr
b
Nelson Mandela African Institution of Science and Technology, PO box 447, Arusha, Tanzania
c
Department of Bioscience and Biotechnology…

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GSK-2838232

New Drug Approvals

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Figure imgf000135_0002

GSK-2838232

4-(((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((3-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid.

28-Norlup-18-en-21-one, 3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(4-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-, (3β)-

Phase I

Glaxosmithkline Llc INNOVATOR

Mark Andrew HATCHER, Brian Alvin Johns,Michael Tolar Martin, Elie Amine TABET, Jun Tang

A reverse transcriptase inhibitor potentially for the treatment of HIV infection.

GSK-2838232; GSK-8232; 2838232

CAS No. 1443460-91-0

C48H73ClN2O6,809.56

SYNTHESIS

PART 1

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PART 4

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AND UNWANTEDISOMER SHOWN BELOW

PART5

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GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection. GSK2838232 is a betulin derivative

Human immunodeficiency virus type 1 (HIV-1 ) leads to the contraction of acquired immune deficiency disease (AIDS). The number of cases of HIV continues to rise, and currently over twenty-five million individuals worldwide suffer from the virus. Presently, long-term suppression of viral replication with antiretroviral drugs is the only option for treating HIV-1 infection. Indeed, the U.S. Food and Drug Administration has approved twenty-five drugs over six…

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Selective reduction of aldehydes and ketones to alcohols with ammonia borane in neat water

Green Chemistry International

Graphical abstract: Selective reduction of aldehydes and ketones to alcohols with ammonia borane in neat water

Chemoselective reduction of various carbonyl compounds to alcohols with ammonia borane (AB), a nontoxic, environmentally benign, and easily handled reagent, in neat water was achieved in quantitative conversions and high isolated yields. Interestingly, α- and β-keto esters were selectively reduced to corresponding hydroxyl esters by AB, while diols were obtained when sodium borohydride was used as a reducing agent. The procedure is also compatible with the presence of a variety of base-labile protecting groups, such as tosyl, acetyl, benzoyl, ester groups, and acid-labile protecting groups such as trityl and TBDMS groups, and others, such as the unsaturated double bond, nitro and cyano groups. Finally, a kilo scale reaction of methyl benzoylformate with AB was conducted in water and gave methyl mandelate in 94% yield.

Selective reduction of aldehydes and ketones to alcohols with ammonia borane in neat water

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DR ANTHONY’S ORGANIC SPECTROSCOPY INTERNATIONAL HITS 4 LAKH VIEWS

New Drug Approvals

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ORGANIC SPECTROSCOPY INTERNATIONAL HITS 4 LAKH VIEWS

LINK https://orgspectroscopyint.blogspot.in/

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ORGANIC SPECTROSCOPY INTERNATIONAL

Organic Chemists from Industry and academics to Interact on Spectroscopy Techniques for Organic Compounds ie NMR, MASS, IR, UV Etc. Starters, Learners, advanced, all alike, contains content which is basic or advanced, by Dr Anthony Melvin Crasto, Worlddrugtracker.

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Domino Hydrogenation−Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines

Green Chemistry International

Domino Hydrogenation−Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines
Org. Lett. 2015, 17, 3990−3993   DOI: 10.1021/acs.orglett.5b01842

Abstract Image

Phenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and in the presence of amines to give the corresponding cyclohexylamines. This reaction works at rt for 12 h or at 60 °C under microwave dielectric heating for 20 min. With the exception of aniline, primary, secondary amines, amino alcohols, and even amino acids can be used as nucleophiles. The reductive process is based on a sustainable hydrogen source and a catalyst that can be efficiently recovered and reused. The protocol was developed into a continuous-flow production of cyclohexylamines in gram scale achieving very efficient preliminary results (TON 32.7 and TOF 5.45 h–1).

Domino Hydrogenation–Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines

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Activated nanostructured bimetallic catalysts for C-C coupling reactions: recent progress

Catal. Sci. Technol., 2016, 6,3341-3361
DOI: 10.1039/C5CY02225H, Minireview
Rohit Kumar Rai, Deepika Tyagi, Kavita Gupta, Sanjay Kumar Singh
This minireview highlights the recent progress made in the last decade towards the development of activated bimetallic alloy nanoparticle catalysts for C-C coupling reactions, including asymmetric C-C bond coupling reactions.
Minireview

Activated nanostructured bimetallic catalysts for C–C coupling reactions: recent progress

*Corresponding authors
aDiscipline of Chemistry, Indian Institute of Technology (IIT) Indore, Simrol, Indore, 452 020 India
bCentre for Material Science and Engineering, Indian Institute of Technology (IIT) Indore, Simrol, Indore, 452 020 India
E-mail: sksingh@iiti.ac.in
Fax: +91 731 2438 933
Catal. Sci. Technol., 2016,6, 3341-3361

DOI: 10.1039/C5CY02225H

Catalysts based on bimetallic nanoparticles have received tremendous scientific and industrial attention and are established as an important class of active catalysts. These catalysts displayed improved catalytic activities compared to their monometallic counterparts for several reactions, which is attributed to their highly modified surface structures (electronic and geometrical) due to the synergic cooperation between the two metals of the bimetallic nanoparticle catalyst. Moreover, such synergic interactions are more prominent in alloy nanoparticle catalysts, where the probability of metal-to-metal interactions is higher in comparison with other systems (such as core–shell nanoparticles). This minireview highlights the recent progress made in the last decade towards the development of activated bimetallic alloy nanoparticle catalysts for C–C coupling reactions, including asymmetric C–C bond coupling reactions. Herein, the influence of the modified electronic structures of the newly formed bimetallic alloy nanoparticle catalysts on their activated catalytic performance is also discussed extensively.
Dr. Sanjay Kumar Singh
Assistant Professor
Chemistry
Organometallics and Nanotech Catalysis Group
Discipline of Chemistry, School of Basic Sciences
Dr. Sanjay Kumar Singh
Assistant Professor
Chemistry
sksingh[at]iiti.ac.in
Mr. Rohit Rai
Ph.D. Student (CSIR-SRF), Since Jan. 2013
He obtained his Masters degree in Organic Chemistry from BHU Varanasi in the year 2012. He is presently engaged in the development of nanoparticle based heterogeneous catalysts for important organic reactions.
rohitrai47[at]gmail.com; phd12123108[at]iiti.ac.in

 

Ms. Deepika Tyagi
Ph.D. Student (UGC-SRF), Since Jan. 2013
She obtained her Masters degree in Organic Chemistry from C.C.S. Meerut University in the year 2011. She is presently engaged in the development of homogeneous catalysts based on organometallic and coordination complexes for important organic reactions.
tyagi.deepika30[at]gmail.com; phd12123112[at]iiti.ac.in
Deepika Tyagi Deepika Tyagi
Ph.D. Scholar
Dr. Sanjay Research Group
M-Block, IIT Indore
Email: phd12123112[at]iiti.ac.in
Research Topic: Development of homogeneous catalysts based on metal complexes for important organic reactions
Ms. Kavita Gupta
Ph.D. Student (CSIR-SRF), Since Jul., 2013
She obtained her Masters degree in Organic Chemistry from Dr. B.R.A. University, Agra in the year 2010. She is presently engaged in the development of catalytic systems for the conversion of bioderived molecules to bio-fuel components and other important products.
phd1301131005[at]iiti.ac.in
ALL AUTHORS
//////Activated nanostructured,  bimetallic catalysts,  C-C coupling reactions,  recent progress