Besifovir, бесифовир , بيسيفوفير , 贝西福韦 ,

New Drug Approvals

Besifovir.svgChemSpider 2D Image | Besifovir | C10H14N5O4PBesifovir.pngBesifovir

  • Molecular FormulaC10H14N5O4P
  • Average mass299.223 Da
  • UNII-4PLG22CQUU
Phosphonic acid, [[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]- [ACD/Index Name]
бесифовир [Russian] [INN]
بيسيفوفير [Arabic] [INN]
贝西福韦 [Chinese] [INN]
((1-((2-Amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphonic acid
[({1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]phosphonic acid
{1-[(2-AMINOPURIN-9-YL)METHYL]CYCLOPROPOXY}METHYLPHOSPHONIC ACID
441785-25-7 [RN]

Besifovir (INN) is an investigational medication to treat hepatitis B virus (HBV) infection. It is a novel and potent acyclic nucleotide phosphonate with a similar chemical structure to adefovir and tenofovir.[2]Image result for BESIFOVIR

Besifovir dipivoxil maleate

CAS:1039623-01-2, Propanoic acid, 2,2-dimethyl-, 1,1′-[[[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphinylidene]bis(oxymethylene)] ester, (2Z)-2-butenedioate (1:1)

Molecular Formula C22 H34 N5 O8 P . C4 H4 O4
 Molecular Weight 643.58
 Highest Phase Launched – 2017, korea

Besifovir dipivoxil maleate

Besifovir, also known as ANA-380; LB-80380; PMCDG dipivoxil, is a reverse transcriptase inhibitor potentially for treatment of hepatitis B infection. LB80380 is a prodrug and an oral nucleotide analogue that inhibits…

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Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4H-pyran-4-one derivatives as antiglioma agents

New Drug Approvals

Med. Chem. Commun., 2018, Advance Article
DOI: 10.1039/C7MD00551B, Research Article
Yi-Bin Li, Wen Hou, Hui Lin, Ping-Hua Sun, Jing Lin, Wei-Min Chen
Two series of 5-hydroxy-2-methyl-4H-pyran-4-one derivatives were synthesized and their antiglioma activities were evaluated.

Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4H-pyran-4-one derivatives as antiglioma agents

Author affiliations

Abstract

D-2-Hydroxyglutarate (D-2HG) is frequently found in human brain cancers. Approximately 50–80% of grade II glioma patients have a high level…

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