2-{[6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl}-4-fluorobenzonitrile (4)
Month: March 2017
Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids
Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids
DOI: 10.1039/C7GC00267J, Paper
Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids for the synthesis of diverse isoquinolines in water.
Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids
E-mail: jiuxichen@wzu.edu.cn


1,3-Diphenylisoquinoline (3a). Pale-yellow solid (103.5 mg, 92%),
mp 78-79 oC (lit.24, 73-74.5 oC). 24 J. D. Tovar and T. M. Swager, J. Org. Chem., 1999, 64, 6499
1H NMR (500 MHz, CDCl3) δ 8.25-8.23 (m, 2H), 8.15-8.14 (m, 1H), 8.09 (s, 1H), 7.95-7.93 (m, 1H), 7.84-7.83 (m, 2H), 7.70-7.67 (m, 1H), 7.59-7.50 (m, 6H), 7.44-7.40 (m, 1H);
13C NMR (125 MHz, CDCl3) δ 160.5, 150.3, 140.1, 139.8, 138.0, 130.4, 130.2, 128.8, 128.7, 128.6, 128.4, 127.7, 127.6, 127.2, 127.0, 126.0, 115.8.
Resolution of Thiele’s acid
Resolution of Thiele’s acid
aDepartment of Chemistry, University of Victoria, P.O. Box 3065 STN CSC, Victoria, BC V8W 3V6, Canada.
bMolecular Structure Facility, Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA.
ABSTRACT
Thiele’s acid has been resolved for the first time by diastereomeric salt formation with brucine. Determination of absolute stereochemistry was accomplished by X-ray crystallography of the corresponding diester. We anticipate that access to optically resolved Thiele’s acid will stimulate its use in a diverse range of applications requiring chiral molecular clefts.
Canadian Journal of Chemistry, 2017, 95(3): 234-238, 10.1139/cjc-2016-0125
(–)-Thiele’s ester 2a as a white solid (200 mg, 81%). Spectral data were consistent with the racemic compound that has been described previously in the literature.5 [α]D 25 = –216 deg mL dm-1 g-1 (c = 0.25, ethanol solution). MP = 87–89 °C.
CCDC 1469300 contains the supplementary crystallographic data for compound (–)-2a. These data are available from the Cambridge Crystallographic Data Centre.
Award for me, 100 Most Impactful Health care Leaders, Global listing
At award function for my award “100 Most Impactful Health care Leaders Global listing”, conferred on me at Taj lands end, Mumbai, India on 14 Feb 2014 by World Health Wellness congress and awards