FACILE MULTI-DECAGRAM SYNTHESIS OF METHYL BUT-2-YNOATE

“Facile multi-decagram synthesis of methyl but-2-ynoate” B. Darses, I. N. Michaelides, D. J. Dixon, Org. Chem. Front. 2014, 1, 117-119

Benjamin Darses,^a   Iacovos N. Michaelides^a and  Darren J. Dixon*^a  

 *Corresponding authors

^aDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK

E-mail: Darren.Dixon@chem.ox.ac.uk

Org. Chem. Front., 2014,1, 117-119

DOI: 10.1039/C3QO00072A

http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/c3qo00072a#!

A high yielding and operationally simple protocol affords multi-decagram quantities of the synthetically useful methyl but-2-ynoate from commercially available starting materials and reagents.

CAS 23326-27-4

MOLINSTINCTS ID:0001-5u7q

Formula:C5H6O2

IUPAC Name:methyl but-2-ynoate

Cite this record :MIID:0001-5u7q

http://search.molinstincts.com/spectra/spectra.ce?0001-5u7q

Synthesis Route for 23326-27-4

67-56-1 Methanol 590-93-2 but-2-ynoic acid

~67%	23326-27-4 methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

Synthesis Route for 23326-27-4

4344-87-0 3-Methyl-3-pyraz… 67-56-1 Methanol

~61%	23326-27-4 methyl but-2-yno…

Reference:

Moriarty, Robert M.; Vaid, Radhe K.; Farid, Payman Journal of the Chemical Society, Chemical Communications, 1987 , # 10 p. 711 – 712

Synthesis Route for 23326-27-4

67-56-1 Methanol 108-26-9 3-methyl-1,4-dih…

~34%	23326-27-4 methyl but-2-yno…

Reference:

Myrboh, B.; Ila, H.; Junjappa, H. Synthesis, 1982 , # 12 p. 1100 – 1102

Synthesis Route for 23326-27-4

186581-53-3 diazomethane 590-93-2 but-2-ynoic acid

23326-27-4 methyl but-2-yno…

Reference:

Aberhart, D. John Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5218 – 5220

Synthesis Route for 23326-27-4

1743-62-0

~73%	23326-27-4 methyl but-2-yno…

Reference:

Boers, Rutger B.; Randulfe, Yolanda Pazos; Van Der Haas, Hendrikus N. S.; Van Rossum-Baan, Marleen; Lugtenburg, Johan European Journal of Organic Chemistry, 2002 , # 13 p. 2094 – 2108

Synthesis Route for 23326-27-4

67-56-1 Methanol 590-93-2 but-2-ynoic acid

~67%	23326-27-4 methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

 

 

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