FACILE MULTI-DECAGRAM SYNTHESIS OF METHYL BUT-2-YNOATE

“Facile multi-decagram synthesis of methyl but-2-ynoate” B. Darses, I. N. Michaelides, D. J. Dixon, Org. Chem. Front. 2014, 1, 117-119

Facile multi-decagram synthesis of methyl but-2-ynoate

 *Corresponding authors
aDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK
Org. Chem. Front., 2014,1, 117-119

DOI: 10.1039/C3QO00072A

http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/c3qo00072a#!

A high yielding and operationally simple protocol affords multi-decagram quantities of the synthetically useful methyl but-2-ynoate from commercially available starting materials and reagents.

Graphical abstract: Facile multi-decagram synthesis of methyl but-2-ynoate

MOLINSTINCTS ID:0001-5u7q

Formula:C5H6O2

IUPAC Name:methyl but-2-ynoate

Cite this record :MIID:0001-5u7q

methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate C-NMR spectrum
methyl but-2-ynoate NMR spectra analysis, Chemical CAS NO. 23326-27-4 NMR spectral analysis, methyl but-2-ynoate H-NMR spectrum

Synthesis Route for 23326-27-4

67-56-1
Methanol
590-93-2
but-2-ynoic acid
~67%
23326-27-4
methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

Synthesis Route for 23326-27-4

4344-87-0
3-Methyl-3-pyraz…
67-56-1
Methanol
~61%
23326-27-4
methyl but-2-yno…

Reference:

Moriarty, Robert M.; Vaid, Radhe K.; Farid, Payman Journal of the Chemical Society, Chemical Communications, 1987 , # 10 p. 711 – 712

Synthesis Route for 23326-27-4

67-56-1
Methanol
108-26-9
3-methyl-1,4-dih…
~34%
23326-27-4
methyl but-2-yno…

Reference:

Myrboh, B.; Ila, H.; Junjappa, H. Synthesis, 1982 , # 12 p. 1100 – 1102

Synthesis Route for 23326-27-4

186581-53-3
diazomethane
590-93-2
but-2-ynoic acid
23326-27-4
methyl but-2-yno…

Reference:

Aberhart, D. John Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5218 – 5220

Synthesis Route for 23326-27-4

1743-62-0
~73%
23326-27-4
methyl but-2-yno…

Reference:

Boers, Rutger B.; Randulfe, Yolanda Pazos; Van Der Haas, Hendrikus N. S.; Van Rossum-Baan, Marleen; Lugtenburg, Johan European Journal of Organic Chemistry, 2002 , # 13 p. 2094 – 2108

Synthesis Route for 23326-27-4

67-56-1
Methanol
590-93-2
but-2-ynoic acid
~67%
23326-27-4
methyl but-2-yno…

Reference:

Viale, Alessandra; Santelia, Daniela; Napolitano, Roberta; Gobetto, Roberto; Dastru, Walter; Aime, Silvio European Journal of Inorganic Chemistry, 2008 , # 28 p. 4348 – 4351

 

 

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 


DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO …..FOR BLOG HOME CLICK HERE

Join me on Linkedin

View Anthony Melvin Crasto Ph.D's profile on LinkedIn

Join me on Facebook FACEBOOK

Join me on twitterFollow amcrasto on Twitter

Join me on google plus Googleplus

 amcrasto@gmail.com

 

 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s