Rapid Wolff-Kishner reductions in a silicon carbide microreactor

Green Chem., 2013, Advance Article
DOI: 10.1039/C3GC41942H, Paper

Stephen G. Newman, Lei Gu, Christoph Lesniak, Georg Victor, Frank Meschke, Lahbib Abahmane, Klavs F. Jensen
Wolff-Kishner reductions are performed continuously in a silicon carbide microreactor. Short reactions times and safe operation are achieved, giving high yields without reactor corrosion issues using just 1.5 equivalents of hydrazine.

Rapid Wolff-Kishner reductions in a silicon carbide microreactor

http://pubs.rsc.org/en/Content/ArticleLanding/2013/GC/C3GC41942H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams

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