Hofmann-Löffler-Freytag reaction

The Hofmann-Löffler-Freytag reaction is over 100 years old but still inspires. This reaction is the earliest example of C-H bond activation and involves migration of an halogen atom in a haloamine along an alkyl chain following by ring closure. 

One thought on “Hofmann-Löffler-Freytag reaction

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s