New cocrystals of ezetimibe with L-proline and imidazole

New Drug Approvals

New cocrystals of ezetimibe with L-proline and imidazole


CrystEngComm, 2014, Advance Article
DOI: 10.1039/C4CE01127A, Paper
Manishkumar R. Shimpi, Scott L. Childs, Dan Bostrom, Sitaram P. Velaga
 *Corresponding authors
aDepartment of Health Sciences Luleå University of Technology, Luleå, Sweden 
bRenovo Research, Atlanta, USA 
cThermal Energy Conversion Laboratory, Department of Applied Physics and Electronics, Umeå University, Umeå S-90187, Sweden

Two new cocrystals of ezetimibe were identified and scale-up. Ezetimibe-proline cocrystal showed improved apparent solubility and physical stability.
The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic phase diagram based high throughput screening was performed using wet…

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