New cocrystals of ezetimibe with L-proline and imidazole

New Drug Approvals

New cocrystals of ezetimibe with L-proline and imidazole

 

CrystEngComm, 2014, Advance Article
DOI: 10.1039/C4CE01127A, Paper
Manishkumar R. Shimpi, Scott L. Childs, Dan Bostrom, Sitaram P. Velaga
 
 *Corresponding authors
aDepartment of Health Sciences Luleå University of Technology, Luleå, Sweden 
bRenovo Research, Atlanta, USA 
cThermal Energy Conversion Laboratory, Department of Applied Physics and Electronics, Umeå University, Umeå S-90187, Sweden
 

Two new cocrystals of ezetimibe were identified and scale-up. Ezetimibe-proline cocrystal showed improved apparent solubility and physical stability.
 
 
The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic phase diagram based high throughput screening was performed using wet…

View original post 151 more words

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s