Minisci reactions: Versatile CH-functionalizations for medicinal chemists

New Drug Approvals

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

Matthew A. J. Duncton*
Renovis, Inc. (a wholly-owned subsidiary of Evotec AG), Two Corporate Drive, South San Francisco, CA 94080, United States. E-mail:; Tel: +1 917-345-3183

Received 24th May 2011 , Accepted 3rd July 2011

First published on the web 22nd August 2011

The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici reaction. Such reactions constitute a broad-set of selective CH-functionalization processes. This review describes some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry, and highlights some potential developments within this area.


The aim of this review is to summarize the use of Minisci reactions within medicinal chemistry…

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