This shouldn’t be a bitter pill to swallow.

Developing the Process

So  the headline caught your attention ? No, oh well, I may try harder next time……..or not.  I thought I might talk about crystallizations today and more specifically about pharmaceutical co-crystals.  If you followed my previous website, PHARMNBIOFUEL.COM, I know that I had covered this topic before.  The gist of using a pharmaceutical co-crystal is to enhance solubility, bioavailability, etc. by adding another chemical entity (this isn’t a salt) that crystallizes with the pharmaceutical of interest.  You can take a look at the following review to read about pharmaceutical co-crystals.

M. Li et al, “Pharmaceutical co-crystals: An Overview”, International Journal of Pharmaceutics, 419 (2011) 1-11, doi: 10.1016/j.ijpharm.2011.07.037

I think it is a familiar story where the final drug product that you attain is as soluble as brick dust and is quite difficult to dissolve in solution.   In fact, the above article mentions that something like less than 1 %…

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