This shouldn’t be a bitter pill to swallow.

Developing the Process

So  the headline caught your attention ? No, oh well, I may try harder next time……..or not.  I thought I might talk about crystallizations today and more specifically about pharmaceutical co-crystals.  If you followed my previous website, PHARMNBIOFUEL.COM, I know that I had covered this topic before.  The gist of using a pharmaceutical co-crystal is to enhance solubility, bioavailability, etc. by adding another chemical entity (this isn’t a salt) that crystallizes with the pharmaceutical of interest.  You can take a look at the following review to read about pharmaceutical co-crystals.

M. Li et al, “Pharmaceutical co-crystals: An Overview”, International Journal of Pharmaceutics, 419 (2011) 1-11, doi: 10.1016/j.ijpharm.2011.07.037

I think it is a familiar story where the final drug product that you attain is as soluble as brick dust and is quite difficult to dissolve in solution.   In fact, the above article mentions that something like less than 1 %…

View original post 247 more words

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s