EFFICIENT CONVERSION OF CARBONYL TO METHYLENE GROUP

 

anicheck.gif (1995 bytes)TEBBE reagent exhibits carbenoid behavior after the addition of a catalytic amout of pyridine.

anicheck.gif (1995 bytes)mechanism:

anicheck.gif (1995 bytes)remarks:

  • The Tebbe’s reagent transfers a methylene group (CH2) efficiently to various carbonyl compounds to afford olefins 

anicheck.gif (1995 bytes)references:

J. Org. Chem. 200671, 5457.
J. Am. Chem. Soc. 1997119, 7483.
J. Am. Chem. Soc. 1993115, 10400.
J. Org. Chem. 198550, 1212.
J. Am. Chem. Soc. 1978100, 3611.

anicheck.gif (1995 bytes)DR A.M. CRASTO

amcrasto@gmail.com

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