Iron-Catalyzed Synthesis of Cyclopropyl Halides

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Iron-Catalyzed Synthesis of Cyclopropyl Halides

ChemCatChem, Current Issue:January 2013

Volume 5, Issue 1

Sabine Grupe and Prof. Dr. Axel Jacobi von Wangelin

Article first published online: 4 JAN 2013 | DOI: 10.1002/cctc.201200740

Under a halo: Selective iron-catalyzed hydrodehalogenations of dibromo- and dichlorocyclopropanes are effectively realized with tBuMgCl as the reductant. The reactions proceed under mild conditions and exhibit superior selectivities to iron-free protocols, as no allenes are formed. The sequential combination of base-mediated dihalocyclopropanation and this mono-dehalogenation provides straightforward access to substituted monohalocyclopropanes.
the supporting info file gives syn and spectral properties

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