Green Lab Notebook app now available on iTunes

Originally posted on Cheminformatics 2.0:

gln_rxneditAfter somewhat more delay than I would have liked, the Green Lab Notebook (GLN) app is now live and available on the iTunes AppStore. The feature set that made its way into version 1.0 was crafted to ensure that editing of multistep reaction experiments and automatic calculation of green chemistry metrics are fully functional, and that importing and exporting features are complete enough to be effective.

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Directing Venom To Fight Cancer ACS Meeting News: Encapsulated venom peptide can skip healthy cells

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Scorpion toxins may one day be useful as anticancer drugs.
Credit: Courtesy of Dipanjan Pan

Venom from scorpions or honeybees sounds like it wouldn’t do a person much good. But by directing a modified component just to tumors, researchers might leverage it into a drug.

Peptides in some venoms bind to cancer cells and block tumor growth and spread. But they have not yet been developed successfully as anticancer agents because they attack healthy cells too.

Bioengineer Dipanjan Pan and coworkers at the University of Illinois, Urbana-Champaign, are now using polymeric nanoparticles to deliver venom toxin directly to cancer cells.

read at

http://cen.acs.org/articles/92/i33/Directing-Venom-Fight-Cancer.html

 

 

 

 

 

Regioselective acetylation of carbohydrates and diols catalyzed by tetramethyl-ammonium hydroxide in water

Regioselective acetylation of carbohydrates and diols catalyzed by tetramethyl-ammonium hydroxide in water

Green Chem., 2014, Advance Article
DOI: 10.1039/C4GC00770K, Communication
Yuchao Lu,a   Peng Wei,a   Yuxin Pei,*a   Hengfu Xu,a  Xiaoting Xina and   Zhichao Pei*ab  
 
*Corresponding authors
aState Key Laboratory of Crop Stress Biology for Arid Areas and College of Science, Northwest A&F University, Yangling, People’s Republic of China 
E-mail: peizc@nwafu.edu.cn, peiyx@nwafu.edu.cn;
Fax: +86 2987092769 ;
Tel: +86 2987091196
bAttana AB, Stockholm, Sweden
A novel method for an efficient regioselective acetylation of carbohydrates and diols in aqueous solution is described.

A novel method for an efficient regioselective acetylation of carbohydrates and diols in aqueous solution is described. Treatment of substrates with 1-acetylimidazole, and tetramethyl-ammonium hydroxide (TMAH) in water under mild conditions gave highly regioselective acetylation for primary hydroxyl groups. This discovery provides an eco-friendly way for selective acetylation of non-protected glycosides and diols in water, avoiding the use of toxic organic solvents and the necessity of pre-protection of secondary hydroxyl groups.

http://pubs.rsc.org/en/Content/ArticleLanding/2014/GC/C4GC00770K?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Seeds Sprout Select Nanotubes Nanotechnology: Chemists create just one type of single-walled carbon nanotube from polycyclic precursor

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A polycyclic aromatic hydrocarbon seed folds up into a cap when heated on a platinum surface. This cap dictates the chirality of the nanotube, approximately 2 nm in diameter, that grows from it.
Credit: Juan Ramon Sanchez-Valencia

Seeds Sprout Select Nanotubes

Nanotechnology: Chemists create just one type of single-walled carbon nanotube from polycyclic precursor
Using a 96-carbon polycyclic aromatic molecule as a seed, chemists have managed to make single-walled carbon nanotubes (SWNTs) of just one type—a long-sought goal in nanotechnology. Being able to make nanotubes of a specific type should help scientists better exploit their promising electronic properties.  read at……………………..

Chitosan: an efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

 

Chitosan: an efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

http://pubs.rsc.org/en/Content/ArticleLanding/2014/GC/C4GC01402B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29

*Corresponding authors
aAcademy of Scientific & Innovative Research, Scale up & Process Engineering Unit, CSIR–Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar-364 002, India
Green Chem., 2014, Advance Article

DOI: 10.1039/C4GC01402B

Chitosan-catalyzed transamidation of carboxamides with amines under solvent-free conditions with a broad substrate scope and recyclability of the catalyst, with one-pot synthesis of benzo[d]heterocycles is described.
A novel chitosan-catalyzed transamidation of carboxamides with amines under solvent-free conditions is described. A series of amide derivatives as well as more challenging aryl and alkyl amines with long-chain alkyl substituents could be selectively converted into the corresponding transamidation products, which are frequently found in biologically active compounds and pharmaceuticals. Under similar reaction conditions benzo[d]heterocycles were also obtained via a one-pot synthesis through transamidation and subsequent dehydration. Recyclability of chitosan was demonstrated, with quantitative yields of products obtained without any loss of catalytic activity.