Elamipretide
H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2
D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide
CAS 736992-21-5
Chemical Formula: C32H49N9O5
Molecular Weight: 639.8
- A free radical scavenger and antioxidant that localizes in the inner mitochondrial membrane.
- Mitochondrial Protective Agent to Improve Cell Viability
- Elamipretide
- bendavia
- UNII-87GWG91S09
- 736992-21-5
- MTP 131
- RX 31
- SS 31
- 87GWG91S09
- L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-
- SS-31 peptide
- Arg-Dmt-Lys-Phe-NH2
- D-Arg-Dmt-Lys-Phe-NH2
- SS31 peptide
- Elamipretide [USAN:INN]
- MTP-131
- Elamipretide (USAN/INN)
- arginyl-2,’6′-dimethyltyrosyl-lysyl-phenylalaninamide
- CHEMBL3833370
- SCHEMBL15028020
- CTK2H1007
Elamipretide (also known as SS-31 and Bendavia)[1][2] is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.[3]
Stealth Peptides, a privately held company, was founded in 2006 to develop intellectual property licensed from several universities including elamipretide; it subsequently changed its name to Stealth BioTherapeutics.[4][5]Acute coronary syndrome; Age related macular degeneration; Cardiac failure; Corneal dystrophy; Diabetic macular edema; Lebers hereditary optic atrophy
- Originator Stealth Peptides
- Developer Stealth BioTherapeutics
- Class Eye disorder therapies; Ischaemic…
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