An efficient Passerini tetrazole reaction (PT-3CR)

Green Chemistry International

Graphical abstract: An efficient Passerini tetrazole reaction (PT-3CR)

An efficient Passerini tetrazole reaction (PT-3CR)

Green Chem., 2016, 18,3718-3721

DOI: 10.1039/C6GC00910G, Communication

Ajay L. Chandgude, Alexander Domling

A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed.

http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00910G?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed. It comprises the reaction of an aldehyde/ketone, an isocyanide and a TMS-azide in methanol : water (1 : 1) as the solvent system. The use of sonication not only accelerated the rate of the reaction but also provided good to excellent quantitative yields. This reaction is applicable to a broad scope of aldehydes/ketones and isocyanides.

An efficient Passerini tetrazole reaction (PT-3CR)

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Corresponding authors
a
Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, 9713 AV…

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