PF-05387552

New Drug Approvals

str1

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STR3

CID 50992153.png

PF-05387552

IRAK4

CAS 1604034-71-0
C25 H27 N5 O2
11H-​Indolo[3,​2-​c]​quinoline-​9-​carbonitrile, 2-​methoxy-​3-​[3-​(4-​methyl-​1-​piperazinyl)​propoxy]​-
2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile
Molecular Weight429.51
Molecular Formula: C25H27N5O2
Molecular Weight: 429.51418 g/mol


Synthesis

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PAPER

Bioorganic & Medicinal Chemistry Letters (2014), 24(9), 2066-2072

Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4

 aPfizer Global R&D, 445 Eastern Point Rd., Groton…

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