Important Industrial Procedures Revisited in Flow: Very Efficient Oxidation and N-Alkylation Reactions with High Atom-Economy

New Drug Approvals

http://www.akademiai.com/content/u87p126856085276/?p=2f48c96a10a64882aeb5c47c657a10b7&pi=4

JournalJournal of Flow Chemistry
PublisherAkadémiai Kiadó
ISSN2062-249X (Print)
2063-0212 (Online)
SubjectFlow Chemistry
IssueVolume 3, Number 2/June 2013
Pages51-58
DOI10.1556/JFC-D-12-00025
Authors
Gellért Sipos1, Viktor Gyollai1, Tamás Sipőcz1, György Dormán1, László Kocsis1 Email for laszlo.kocsis@thalesnano.com, Richard V. Jones1, Ferenc Darvas1

1ThalesNano Zahony u. 7 1031 Budapest Hungary

Abstract

The atom economy concept is one of the earliest recognition for green and sustainable aspects of organic synthesis. Over the years, novel technologies emerged that made this important feature of reactions into practice. Continuous-flow devices increased the efficiency of the chemical transformations with novel process windows (high T, high p and heterogeneous packed catalysts etc.) and increased safety which turned the attention to reexamine old, industrial processes. Oxidation can be performed under flow catalytic conditions with molecular oxygen; alcohols can be oxidized to…

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