Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

Green Chemistry International

abstract graphic

Molecules2014, 19(12), 19665-19677; doi:10.3390/molecules191219665

A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.

Molecules2014, 19(12), 19665-19677; doi:10.3390/molecules191219665

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