Conversion of carbonyl compounds to alkynes: general overview and recent developments

The preparation of alkynes from carbonyl compounds via a one-carbon homologation has become a very useful pathway for the synthesis of acetylenic compounds, both internal and terminal. This tutorial review provides an overview of the different methods available for this transformation, including their scope and limitations, recent developments and applications in total syntheses.

Damien Habrant,^a   Vesa Rauhala^a and   Ari M. P. Koskinen*^a  

*Corresponding authors

^aLaboratory of Organic Chemistry, Aalto University School of Science and Technology, FIN-00076 Aalto, Finland

E-mail: ari.koskinen@tkk.fi;
Fax: +358-9-470 22538 ;
Tel: +358-9-470 22526

Chem. Soc. Rev., 2010,39, 2007-2017

DOI: 10.1039/B915418C

http://pubs.rsc.org/en/content/articlelanding/2010/cs/b915418c#!divAbstract

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