IMPROVED CONTINUOUS FLOW PROCESSING: BENZIMIDAZOLE RING FORMATION VIA CATALYTIC HYDROGENATION OF AN AROMATIC NITRO COMPOUND

Figure

 

Improved Continuous Flow Processing: Benzimidazole Ring Formation via Catalytic Hydrogenation of an Aromatic Nitro Compound

 

http://pubs.acs.org/doi/full/10.1021/op400179f

pp 1427–1433
Publication Date (Web): August 6, 2013 (Article)
DOI: 10.1021/op400179f

In the development of a new route to bendamustine hydrochloride, the API in Treanda, the key benzimidazole intermediate 5 was generated via catalytic heterogeneous hydrogenation of an aromatic nitro compound using a batch reactor. Because of safety concerns and a site limitation on hydrogenation at scale, a continuous flow hydrogenation for the reaction was investigated at lab scale using the commercially available H-Cube. The process was then scaled successfully, generating kilogram quantities on the H-Cube Midi. This flow process eliminated the safety concerns about the use of hydrogen gas and pyrophoric catalysts and also showed 1200-fold increase in space–time yield versus the batch processing.

One thought on “IMPROVED CONTINUOUS FLOW PROCESSING: BENZIMIDAZOLE RING FORMATION VIA CATALYTIC HYDROGENATION OF AN AROMATIC NITRO COMPOUND

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s