Dr. Crasto’s news on Continuous flow for drug synthesis

SynthFlow

As I mentioned in the past week, I will take some time to provide some of Anthony Melvin Crasto’s information of flow approaches to drug discovery and API synthesis — maybe I should rename this CF list of the week – we shall see. It certainly opened my eyes to how much work is going on in pushing flow chemistry to application in drug discovery — and so many of our readers want to keep up with the latest thoughts and trends. Here is this week’s news:

CF for Rufinamide

A report (Org Process Res Dev 2014, ASAP article) out of Jamison’s group at MIT, provides a 3-step synthesis of Rufinamide in 92% overall yield. The process illustrates a continuous and convergent method, moving away from the isolation of a key organic azide intermediates and a Cu coiled-tube reactor for the cycloaddition reaction to the corresponding desired triazole.

View original post 222 more words

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s