Evaluation of Pd-catalyzed hydrogenations under flow conditions

SynthFlow

Just finished reading an excellent example from a group in Japan moving a batch hydrogenation to flow. Dr Sajiki’s group developed and evaluated a number of Pd-catalysts and their effectiveness in an H-Cube (Thales Nano) reactor. This evaluation went into detail on both reaction optimization and chemoselectivities, depending on the catalyst type — while scoping a variety of temp, flow and solvents for each of the reactions — it was truly impressive how much work was performed and the amount of information we obtain for the work done. The work was published in Tetrahedron 2014 and featured and a highlight brief in Synfacts 2014.

From the cartoon below, you can see that the substrate was passed through a series of immobilized Pd catalysts to provide different targets depending on their functionality. A variety of pressures, flow rates, and substrate concentrations were studied as part of the optimization process.

Screen Shot 2014-10-18 at 2.27.51 PM

Rather than…

View original post 66 more words

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s