.Continuous preparation of arylmagnesium reagents in flow with in-line IR monitoring

.Continuous preparation of arylmagnesium reagents in flow with in-line IR monitoring

T. Brodmann, P. Koos, A. Metzger, P. Knochel, S.V. Ley, Org. Proc. Res. Dev. 2012, 16, 1102-1113.

http://pubs.acs.org/doi/abs/10.1021/op200275d

A newly developed microscale ReactIR flow cell was used as a convenient and versatile inline analytical tool for Grignard formation in continuous flow chemical processing. The LiCl-mediated halogen/Mg exchange reaction was used for the preparation of functionalized arylmagnesium compounds from aryl iodides or bromides. Furthermore, inline IR monitoring was used for the analysis of conversion and possible byproduct formation, as well as a potential tool for elucidation of mechanistic details. The results described herein indicate that the continuous flow systems are effective for highly exothermic reactions such as the Grignard exchange reaction due to fast mixing and efficient heat transfer.

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2 thoughts on “.Continuous preparation of arylmagnesium reagents in flow with in-line IR monitoring

  1. It is interesting that a method that was so successfull in clinical diagnostics early on has been adapted to industrial processes. The cryoflow reactor I’m not familiar with. In the formation of the endproduct there must be a drop in temperature which is linearly related to the reaction rate. What is that called? It’s not exothermic, is it?

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