From Termite Fumigant to Molecular Coupling
Sulfur fluoride exchange – a powerful new reaction for click chemistry
Sulfur Fluoride Exchange – a Powerful New Reaction
A team led by Sharpless at The Scripps Research Institute in La Jolla (CA, USA) has now developed another groundbreaking click reaction: sulfur fluoride exchange (SuFEx). This reaction exploits the very special reactivity of sulfur fluorides and makes it possible for chemists to bind together molecules of their choice. Like most click reactions, the process itself is an old one that has been improved to allow the previously underestimated sulfate bond to be used as a universally applicable connector for linking a variety of molecular building blocks.