Polymorphs and co-crystals of haloprogin: an antifungal agent

New Drug Approvals


Haloprogin is a topical antifungal agent. Its structure does not contain any of the functional groups typically exploited in hydrogen bond based co-crystal design. On the other hand, its 1-iodoalkyne moiety is nicely tailored to a crystal engineering strategy based on halogen bonding. Here we describe the formation of three polymorphs of haloprogin and of three co-crystals that this active pharmaceutical ingredient forms with both neutral and ionic co-crystal formers. The halogen bond plays a major role in all of the six structures and the interaction is thus confirmed to be a valuable tool which may complement the hydrogen bond when polymorphs and co-crystals of active pharmaceutical ingredients are pursued.

Graphical abstract: Polymorphs and co-crystals of haloprogin: an antifungal agent

Graphical abstract: Polymorphs and co-crystals of haloprogin: an antifungal agent

Polymorphs and co-crystals of haloprogin: an antifungal agent

Michele Baldrighi,a Davide Bartesaghi,a Gabriella Cavallo,a Michele R. Chierotti,b Roberto Gobetto,b Pierangelo Metrangolo,*a Tullio Pilati,a Giuseppe Resnati*a and Giancarlo Terraneo*a

View original post 358 more words

Knowledge-based approaches to co-crystal design

New Drug Approvals

Knowledge-based approaches to co-crystal design – CrystEngComm (RSC Publishing) //

Graphical abstract: Knowledge-based approaches to co-crystal design

Peter A. Wood, Neil Feeder, Matthew Furlow, Peter T. A. Galek, Colin R. Groom and Elna Pidcock

CrystEngComm, 2014, 16, 5839 DOI:10.1039/C4CE00316K


Knowledge-based approaches to co-crystal design – CrystEngComm (RSC Publishing) //

Knowledge-based approaches to co-crystal design

*Corresponding authors
aCambridge Crystallographic Data Centre, 12 Union Road, Cambridge, UK

View original post 16 more words

Exploring a parasitic tunnel boring machine

Lyra Nara Blog

Exploring a parasitic tunnel boring machine

Scanning electron micrograph of an adult whipworm roundworm parasite. Credit: Uta Rössler, Toby Starborg, Allison Bancroft and Richard Grencis, The University of Manchester.

Researchers have deduced essential biological and genetic information from the genome sequence of the whipworm, an intestinal parasitic worm that infects hundreds of millions of people in developing countries.

This information acts as the foundation for the development of new strategies and treatments against this debilitating parasite.

The whipworm is one of three types of soil-transmitted parasitic worms that collectively infect nearly two billion people. While infections often result in mild disease they may also lead to serious and long-term damage such as malnutrition, stunted growth and impaired learning ability. The full extent of worm-associated morbidity and the effect it has on socio-economic development in endemic countries is unknown.

This unusual parasite bores miniature tunnels through the lining of the large intestine where it may live for…

View original post 660 more words





A two-step tandem reaction to prepare hydroxamic acids directly from alcohols – Organic & Biomolecular Chemistry (RSC Publishing) //

*Corresponding authors
aDipartimento di Chimica e Farmacia, Università degli Studi di Sassari, via Vienna 2, 07100 Sassari, Italy
Org. Biomol. Chem., 2014,12, 4582-4585

DOI: 10.1039/C4OB00693C



‘Trust hormone’ oxytocin helps old muscle work like new, study finds

Lyra Nara Blog

'Trust hormone' oxytocin helps old muscle work like new, study finds

On the left is healthy muscle tissue from a young mouse. The ability of muscle to repair itself decreases with age, as evidenced by the middle image of old muscle tissue, which shows a lower density of muscle fibers, increased scar tissue and inflammation. The addition of oxytocin to the blood of old mice rapidly rejuvenates the old muscle, as shown in the image on the right. Credit: Wendy Cousin and Christian Elabd, UC Berkeley.

Researchers at the University of California, Berkeley, have discovered that oxytocin—a hormone associated with maternal nurturing, social attachments, childbirth and sex—is indispensable for healthy muscle maintenance and repair, and that in mice, it declines with age.

The new study, to be published Tuesday, June 10, in the journal Nature Communications, presents oxytocin as the latest treatment target for age-relatedmuscle wasting, or sarcopenia.

A few other biochemical factors in blood have been connected to…

View original post 898 more words