Recent Progress in the Synthesis of Tamiflu

New Drug Approvals

ABOVE PICTURE-The synthetic route to tamiflu reported by M. Shibasaki starting from 1,4-cyclohexadiene. See JACS 2006, 128, 6312-6313
    SEE  CHINESE ARTICLE ON  Recent Progress in the Synthesis of Tamiflu
Zhang Tiancai, Lu Hui, Zhang Fu-Min, Cheng Jun, Liu Tianyang
2013, 33 (06), pp 1235-1243
Publication Date: 25 June 2013 (Reviews)
Abstract  Tamiflu, one of the most common orally drugs for the treatment and prevention of influenza, has attracted extensive interests of synthetic chemists all over the world.Concise, efficient, and scalable synthetic approaches toward this molecule have been a very active field in recent years, and many diverse synthetic routes have been developed to date.In this review, representative synthetic routes employing chiral starting material or catalytic asymmetric reactions are briefly summarized.
Fund:Project supported by the National Natural Science Foundation of China (Nos.20972059, 21290180), the Program for Changjiang Scholars and Innovative Research Team in…

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