Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

Manoj B. Gawande,*^a   Vasco D. B. Bonifácio,*^a   Rafael Luque,^b  Paula S. Branco^a and   Rajender S. Varma*^c

Chem. Soc. Rev., 2013, Advance Article

http://pubs.rsc.org/en/content/articlelanding/2013/cs/c3cs60025d

DOI: 10.1039/C3CS60025D
Received 25 Jan 2013, First published online 26 Mar 2013

Catalyst-free reactions developed during the last decade and the latest developments in this emerging field are summarized with a focus on catalyst-free reactions in-water and on-water.

Various named reactions, multi-component reactions and the synthesis of heterocyclic compounds are discussed including the use of various energy input systems such as microwave- and ultrasound irradiation, among others.

Organic chemists and the practitioners of this art both in academia and industry hopefully will continue to design benign methodologies for organic synthesis in aqueous media under catalyst-free conditions by using alternative energy inputs based on fundamental principles.

http://pubs.rsc.org/en/content/articlelanding/2013/cs/c3cs60025d

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