Convenient One-Pot Two-Step Synthesis of 1,3-Thiazoles via Organocatalyzed Epoxidation of Nitroolefins

Shengwei Wei, Katharina M. Weiß, Svetlana B. Tsogoeva*

Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany

Synthesis 2012; 44(22): 3441-3446
DOI: 10.1055/s-0031-1291139
practical synthetic procedures

A convenient novel one-pot two-step strategy and its substrate scope for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitroolefins with the TBHP/DBU system, and subsequent reaction of α-nitroepoxides with thioamides is reported.

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