Sertraline hydrochloride (trade names Zoloft and Lustral, among others) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was discovered by Pfizer. Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in both adults and children
Schematic Representation for Synthesis of Sertraline
i. Benzene, anhydrous aluminum chloride, dichloromethane,
ii. Diethyl succinate, potassium-t-butoxide, t-butyl alcohol, reflux, 16 h,
iii. 48% aqueous HBr, acetic acid, reflux, 36 h,
iv. Hydrogen gas (1 atm), 5% Pd/c catalyst, ethyl acetate, room temperature, 24 h,
v. a) Thionyl chloride, toluene, reflux, 75 min b) anhydrous aluminum chloride, carbon disulfide, room temperature, 16 h,
vi. Methylamine, tetrahydrofuran, titanium tetrachloride, room temperature, 17 h,
vii. a) Hydrogen gas (1 atm), 10% Pd/c catalyst, tetrahydrofuran, room temperature, 2 h b) Gaseous hydrogen chloride,
viii. Crystallization from methanol and ether,
ix) a) 20% sodium hydroxide, ethyl acetate b) D (-) Mandelic acid, ethanol, resolution
CAS No:- [79617-96-2]
IUPAC Name:- (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
Drug information:- Sertraline is an anti-depressant drug.
DR ANTHONY MELVIN CRASTO Ph.D
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