CLOPIDOGREL ENANTIOMER ENRICHMENT

Abstract Image

 

The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield.

Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel – A Practical Application of a New Discovery

Org. Process Res. Dev., 2009, 13 (6), pp 1195–1198
DOI: 10.1021/op900243c
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