SPIROINDOLINES – RADICAL CYCLIZATIONS OF UGI-4CR-PRODUCTS

spiroindolines – Radical cyclizations of Ugi-4CR-Products

Laurent El Kaim, Laurence Grimaud, Xavier-Frédéric Le Goff, Martha Menes-Arzate and Luis D. Miranda

[1] DOI: http://dx.doi.org/10.1039/c1cc12236c

[2] DOI: http://dx.doi.org/doi:10.1016/j.tetlet.2006.09.123

[3] DOI: http://dx.doi.org/10.1055/s-0029-1218700

[4] DOI: http://dx.doi.org/10.1021/ol701678d

In this paper they were able to cyclize the primary Ugi-adduct under copper(II) catalysis to yield spiroindolines with drug-like structures

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