BENAZEPRIL HYDROCHLORIDE SYNTHESIS AND REVIEW

Originally posted on New Drug Approvals:

BENAZEPRIL HYDROCHLORIDE, CAS NO 86541-74-4

Benazepril, brand name Lotensin (Novartis), is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Dosage forms

Benazepril is available as oral tablets, in 5-, 10-, 20-, and 40-mg doses.

Benazepril is also available in combination with hydrochlorothiazide, under the trade name Lotensin HCT, and with amlodipine(trade name Lotrel).

Side effects

Most commonly, headaches and cough can occur with its use. Anaphylaxisangioedema and hyperkalemia, the elevation of potassium levels, can also occur.

Benazepril may cause harm to the fetus during pregnancy.

According to coverage of the study on WebMD:

ACE inhibitors can pose a potential threat to kidneys as well…

View original 3,076 more words

About these ads

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s